TBX4

Across TCGA cell cohorts, TBX4 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBX4-associated genes across cancer lineages are BANF2, MS4A6E, and RXFP3. Each is linked with TBX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX4-to-partner and partner-to-TBX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BANF2 grouped by TBX4-low versus TBX4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX4→partner) and Y-score (partner→TBX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	BANF2 →	+0.146	+4.906	<.001	.006	3	1
OESOPHAGUS	MS4A6E →	+0.050	+4.906	<.001	.006	3	1
OESOPHAGUS	RXFP3 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	OR8B4 →	+0.036	+4.906	<.001	.006	3	1
BLOOD_Leukemia	CYP11B1 →	+0.056	+3.234	<.001	.008	3	1
BLOOD_Leukemia	SFTPC →	+0.066	+3.714	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

BANF2 by TBX4 expression — OESOPHAGUS

Explore this box plot interactively →