TBX3

Across TCGA cell cohorts, TBX3 mutation is significantly associated with the RNA expression of many other genes, with 358 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBX3-associated genes across cancer lineages are CATSPER3, RCC1, and OR2V2. Each is linked with TBX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX3-to-partner and partner-to-TBX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CATSPER3 grouped by TBX3-low versus TBX3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX3→partner) and Y-score (partner→TBX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CATSPER3 →	+0.419	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	RCC1 →	+0.542	+2.158	.005	.004	3	2
LARGE_INTESTINE	OR2V2 →	+0.008	+2.148	.001	.001	3	2
LUNG_SCLC	OR2D2 →	+0.044	+3.898	.005	.005	3	1
LUNG_SCLC	OR2M7 →	+0.024	+4.058	<.001	.007	3	1
LUNG_SCLC	SPATA31A6 →	+0.083	+4.256	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 358 associations by consensus.

CATSPER3 by TBX3 expression — LARGE_INTESTINE

Explore this box plot interactively →