TBX22

Across TCGA patient cohorts, TBX22 mutation is significantly associated with the RNA expression of many other genes, with 3,659 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX22-associated genes across cancer lineages are ABHD10, GEMIN2, and SUV39H2. Each is linked with TBX22 in more than 3 cancer types. Because this analysis shows association rather than direction, both TBX22-to-partner and partner-to-TBX22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABHD10 grouped by TBX22-low versus TBX22-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX22→partner) and Y-score (partner→TBX22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ABHD10 →	+0.327	+3.087	.006	<.001	3	4
LUSC	GEMIN2 →	+0.440	+2.643	<.001	<.001	3	4
UCEC	SUV39H2 →	+0.408	+1.679	.005	.006	3	3
UCEC	GPR180 →	+0.390	+1.857	.001	<.001	3	3
UCEC	TEDC2 →	+0.502	+2.120	<.001	<.001	3	3
LUSC	C1orf52 →	+0.257	+2.700	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,659 associations by consensus.

ABHD10 by TBX22 expression — LUSC

Explore this box plot interactively →