TBX22

Across TCGA pan-cancer cohorts, TBX22 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated TBX22 data layer compared with 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TBX22 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBX22 expression acts as an unfavorable survival marker, although some lineages such as ESCA and ACC show a favorable association.

UCEC, MESO, and LUAD are the cancer types where TBX22 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.533	0.735	<.001	96	view →
MESO	OS	Tertile	III,IV	0.404	0.605	.012	36	view →
LUAD	DFS	Tertile	IV	0.132	0.657	.001	36	view →
COAD	DFS	Tertile	III,IV	0.137	0.654	<.001	30	view →
KICH	DFS	Quartile	All	0.688	1.000	.008	24	view →
KIRC	DFS	Quartile	All	0.695	0.827	.012	24	view →
ESCA	OS	Tertile	IV	0.743	0.290	.013	24	view →
ACC	OS	Median	All	0.898	0.726	.015	23	view →
KIRP	OS	Tertile	All	0.795	0.919	.012	21	view →
SCLC	DFS	Tertile	All	0.055	0.567	<.001	18	view →
READ	DFS	Tertile	IV	0.027	0.636	<.001	9	view →
UVM	DFS	Tertile	All	0.368	0.649	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

TBX22–UCEC (DFS)

Open the UCEC breakdown →