TBX22

Across TCGA cell cohorts, TBX22 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBX22-associated genes across cancer lineages are REG1B, AMY1B, and AMY1A. Each is linked with TBX22 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX22-to-partner and partner-to-TBX22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by TBX22-low versus TBX22-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX22→partner) and Y-score (partner→TBX22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	REG1B →	+0.269	+4.392	.003	.003	3	1
OESOPHAGUS	AMY1B →	+0.023	+4.392	.001	.003	3	1
OESOPHAGUS	AMY1A →	+0.023	+4.392	.001	.003	3	1
OESOPHAGUS	CHAT →	+0.105	+4.017	.007	.007	3	1
LARGE_INTESTINE	SH3GL2 →	+1.345	+3.252	<.001	.009	3	1
LARGE_INTESTINE	BHMT →	+0.436	+3.392	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

REG1B by TBX22 expression — OESOPHAGUS

Explore this box plot interactively →