TBX21

Across TCGA patient cohorts, TBX21 protein abundance is significantly associated with the RNA expression of many other genes, with 5,039 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TBX21-associated genes across cancer lineages are IL2RB, MAP4K1, and LILRB1. Each is linked with TBX21 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBX21-to-partner and partner-to-TBX21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TBX21 versus IL2RB in BRCA, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX21→partner) and Y-score (partner→TBX21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IL2RB →	+1.625	+0.859	<.001	<.001	3	3
LSCC	MAP4K1 →	+1.179	+0.848	<.001	<.001	3	3
LSCC	LILRB1 →	+0.793	+0.546	<.001	<.001	3	3
BRCA	CD79A →	+2.265	+0.638	<.001	.004	3	3
BRCA	P2RX1 →	+1.101	+0.742	<.001	.001	3	3
LSCC	IFNG →	+1.566	+0.943	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,039 associations by consensus.

TBX21 vs IL2RB — BRCA

Explore this scatter interactively →