TBX21

Across TCGA patient cohorts, TBX21 protein abundance is significantly associated with the protein abundance of many other proteins, with 8,959 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TBX21-associated proteins across cancer lineages are PLEK, PLEKHO1, and POU2F2. Each is linked with TBX21 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBX21-to-partner and partner-to-TBX21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TBX21 versus PLEK in LSCC, with a Pearson correlation of 0.50.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX21→partner) and Y-score (partner→TBX21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLEK →	+0.574	+0.732	<.001	<.001	3	3
LUAD	PLEKHO1 →	+0.492	+0.835	<.001	<.001	3	3
LUAD	POU2F2 →	+1.021	+0.743	<.001	<.001	3	3
LSCC	POU2F2_S55 →	+1.071	+0.860	.001	<.001	3	3
BRCA	PTPN7 →	+0.579	+0.583	<.001	<.001	3	3
LSCC	PTPRC →	+0.839	+0.949	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,959 associations by consensus.

TBX21 vs PLEK — LSCC

Explore this scatter interactively →