TBX21

Across TCGA patient cohorts, TBX21 mutation is significantly associated with the RNA expression of many other genes, with 1,537 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX21-associated genes across cancer lineages are NDUFA5P4, ANKRD33B-AS1, and MIR4774. Each is linked with TBX21 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBX21-to-partner and partner-to-TBX21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA5P4 grouped by TBX21-low versus TBX21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX21→partner) and Y-score (partner→TBX21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFA5P4 →	+0.128	+2.889	.008	.001	3	3
COAD	ANKRD33B-AS1 →	+0.308	+4.893	<.001	.005	3	2
COAD	MIR4774 →	+1.798	+6.101	<.001	<.001	3	2
READ	RN7SL612P →	+0.364	+5.219	<.001	.006	3	2
LUSC	RNU1-23P →	+0.189	+5.321	<.001	.002	3	2
LUSC	LINC02674 →	+0.155	+5.321	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,537 associations by consensus.

NDUFA5P4 by TBX21 expression — UCEC

Explore this box plot interactively →