TBX21

Across TCGA patient cohorts, TBX21 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX21-associated genes across cancer lineages are c-Met_pY1235, eEF2, and p53. Each is linked with TBX21 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBX21-to-partner and partner-to-TBX21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by TBX21-low versus TBX21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX21→partner) and Y-score (partner→TBX21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.074	+3.009	.039	.019	3	3
UCEC	eEF2 →	+0.423	+2.459	.014	.020	3	2
SKCM	p53 →	+0.440	+2.820	<.001	.035	3	1
UCEC	FoxM1 →	+0.329	+2.459	.008	.020	3	1
UCEC	GATA6 →	-0.204	-3.000	.008	.035	3	1
UCEC	ACVRL1 →	-0.203	-3.150	.001	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

c-Met_pY1235 by TBX21 expression — UCEC

Explore this box plot interactively →