TBX21

Across TCGA cell cohorts, TBX21 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,998 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TBX21-associated GO terms across cancer lineages are Regulation of RNA splicing, U2-type prespliceosome assembly, and Regulation of DNA repair. Each is linked with TBX21 in more than 6 cancer types. Because this analysis shows association rather than direction, both TBX21-to-partner and partner-to-TBX21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by TBX21-low versus TBX21-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX21→partner) and Y-score (partner→TBX21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of RNA splicing →	+0.050	+0.028	.001	.005	3	7
LARGE_INTESTINE	U2-type prespliceosome assembly →	+0.050	+0.011	.008	.007	3	7
STOMACH	Regulation of DNA repair →	+0.043	+0.031	.004	.004	2	7
LUNG_NSCLC_LUAD	Microtubule polymerization or depolymerization →	+0.052	+0.104	.003	.007	3	6
LARGE_INTESTINE	Spliceosomal snRNP assembly →	+0.069	+0.014	<.001	.004	3	6
LUNG_SCLC	Negative regulation of mRNA metabolic process →	+0.041	+0.194	.005	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,998 associations by consensus.

Regulation of RNA splicing by TBX21 expression — BREAST

Explore this box plot interactively →