TBX2-AS1

Across TCGA pan-cancer cohorts, TBX2-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TBX2-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TBX2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBX2-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and BLCA show a favorable association.

ACC, UVM, and KIRP are the cancer types where TBX2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.194	0.688	<.001	113	view →
UVM	OS	Quartile	All	0.980	0.711	.001	69	view →
KIRP	DFS	Tertile	All	0.849	0.966	.001	51	view →
BLCA	DFS	Median	All	0.575	0.447	.002	49	view →
SARC	DFS	Tertile	All	0.494	0.721	.003	19	view →
KIRC	DFS	Quartile	IV	0.242	0.634	.018	17	view →
LGG	OS	Median	All	0.974	0.838	<.001	16	view →
LAML	DFS	Median	All	0.547	0.377	.007	12	view →
PAAD	DFS	Median	II,III,IV	0.559	0.373	.031	10	view →
DLBC	DFS	Median	II,III,IV	0.971	0.592	.023	8	view →
THCA	DFS	Quartile	All	0.983	0.916	.019	8	view →
KICH	DFS	Median	All	1.000	0.673	.017	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TBX2-AS1–ACC (DFS)

Open the ACC breakdown →