TBX2-AS1

Across TCGA pan-cancer cohorts, TBX2-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TBX2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TBX2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types TBX2-AS1 is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, LUAD, and LUSC are the cancer types where TBX2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBX2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.192	<.001	12	view →
LUAD	Female	III,IV	−2.368	<.001	9	view →
LUSC	Male	III,IV	−2.364	<.001	8	view →
LIHC	All	II,III,IV	+0.885	<.001	8	view →
KIRP	Male	All	−1.867	<.001	7	view →
KICH	Male	All	−1.345	<.001	7	view →
COAD	All	III,IV	−0.417	.006	7	view →
UCEC	All	All	−2.106	<.001	6	view →
BRCA	All	All	−0.980	<.001	6	view →
THCA	All	II,III,IV	−0.924	.013	5	view →
HNSC	All	II,III,IV	+0.468	.015	4	view →
CHOL	All	All	+1.101	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TBX2-AS1–KIRC

Open the KIRC breakdown →