TBX19

Across TCGA patient cohorts, TBX19 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX19-associated genes across cancer lineages are eIF4E, JNK2, and VHL. Each is linked with TBX19 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX19-to-partner and partner-to-TBX19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TBX19-low versus TBX19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX19→partner) and Y-score (partner→TBX19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.154	+3.472	.035	.002	3	2
UCEC	JNK2 →	+0.242	+3.348	<.001	.004	3	2
UCEC	VHL →	-0.838	-1.906	<.001	.015	3	2
UCEC	ATM →	-0.537	-1.440	<.001	.024	3	2
UCEC	ERK2 →	+0.213	+2.087	.001	.005	3	1
UCEC	Ku80 →	+0.192	+1.453	.018	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eIF4E by TBX19 expression — UCEC

Explore this box plot interactively →