TBX19

Across TCGA pan-cancer cohorts, TBX19 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TBX19’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TBX19 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TBX19 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRC, HNSC, and BLCA are the cancer types where TBX19 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBX19 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.105	<.001	12	view →
HNSC	All	III,IV	+0.520	<.001	11	view →
BLCA	All	III,IV	+0.730	<.001	9	view →
LIHC	Female	II,III,IV	+0.725	<.001	9	view →
KICH	Female	All	−1.152	<.001	8	view →
KIRP	All	All	+0.371	.003	8	view →
BRCA	Female	All	−0.364	<.001	6	view →
CHOL	Male	All	+1.986	<.001	5	view →
STAD	All	All	+0.516	.001	5	view →
COAD	All	II,III,IV	+0.270	.002	4	view →
ESCA	All	All	+0.719	.006	2	view →
LUSC	All	All	+0.334	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TBX19–KIRC

Open the KIRC breakdown →