TBX15

Across TCGA patient cohorts, TBX15 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX15-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and eIF4E. Each is linked with TBX15 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBX15-to-partner and partner-to-TBX15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TBX15-low versus TBX15-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX15→partner) and Y-score (partner→TBX15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.173	+2.824	.002	.034	3	3
UCEC	EGFR_pY1068 →	-0.236	-2.000	.004	.009	3	2
UCEC	eIF4E →	+0.191	+3.820	.006	<.001	3	2
UCEC	mTOR_pS2448 →	-0.117	-1.986	.019	.008	3	2
UCEC	p62 Lck ligand →	+0.304	+2.232	.005	.005	3	2
UCEC	Shc_pY317 →	-0.158	-1.906	.001	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Caspase-7-cleavedD198 by TBX15 expression — COAD

Explore this box plot interactively →