TBX15

Across TCGA cell cohorts, TBX15 mutation is significantly associated with the RNA expression of many other genes, with 126 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBX15-associated genes across cancer lineages are SPACA5B, PLA2G2C, and PRR9. Each is linked with TBX15 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX15-to-partner and partner-to-TBX15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPACA5B grouped by TBX15-low versus TBX15-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX15→partner) and Y-score (partner→TBX15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SPACA5B →	+0.167	+4.643	<.001	.004	3	1
LUNG_SCLC	PLA2G2C →	+0.143	+4.044	.003	.009	3	1
LUNG_SCLC	PRR9 →	+0.092	+4.523	<.001	.003	3	1
BLOOD_Lymphoma	BMP15 →	+0.029	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	A3GALT2 →	+0.027	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	IQCF5 →	+0.116	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 126 associations by consensus.

SPACA5B by TBX15 expression — LUNG_SCLC

Explore this box plot interactively →