TBRG4

Across TCGA patient cohorts, TBRG4 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBRG4-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and MSH2. Each is linked with TBRG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBRG4-to-partner and partner-to-TBRG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TBRG4-low versus TBRG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBRG4→partner) and Y-score (partner→TBRG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.194	+2.820	<.001	.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.797	+2.242	<.001	.005	3	3
UCEC	MSH2 →	-0.377	-2.896	<.001	.001	3	2
UCEC	MSH6 →	-0.332	-3.321	.007	.009	3	2
UCEC	ERK2 →	+0.189	+1.765	.008	.014	3	1
UCEC	JNK_pT183_Y185 →	-0.156	-1.752	.013	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Notch1 by TBRG4 expression — UCEC

Explore this box plot interactively →