TBRG4

Across TCGA cell cohorts, TBRG4 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBRG4-associated genes across cancer lineages are CRISP2, C1orf189, and SSMEM1. Each is linked with TBRG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBRG4-to-partner and partner-to-TBRG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRISP2 grouped by TBRG4-low versus TBRG4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBRG4→partner) and Y-score (partner→TBRG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRISP2 →	+0.018	+3.882	<.001	.001	3	1
LARGE_INTESTINE	C1orf189 →	+0.184	+4.376	<.001	<.001	3	1
LARGE_INTESTINE	SSMEM1 →	+0.023	+4.029	.003	.002	3	1
LARGE_INTESTINE	KRT1 →	+0.456	+3.509	.001	.008	3	1
LARGE_INTESTINE	FDCSP →	+0.650	+3.453	<.001	.009	3	1
LARGE_INTESTINE	ELOA3DP →	+0.030	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

CRISP2 by TBRG4 expression — LARGE_INTESTINE

Explore this box plot interactively →