TBR1

Across TCGA cell cohorts, TBR1 mutation is significantly associated with the RNA expression of many other genes, with 265 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBR1-associated genes across cancer lineages are SLC39A12, PPP4R3A, and DNAJC3. Each is linked with TBR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBR1-to-partner and partner-to-TBR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC39A12 grouped by TBR1-low versus TBR1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBR1→partner) and Y-score (partner→TBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC39A12 →	+0.171	+2.906	.001	.007	3	2
LARGE_INTESTINE	PPP4R3A →	+0.600	+3.451	<.001	.002	3	1
LARGE_INTESTINE	DNAJC3 →	+0.605	+3.364	.002	.002	3	1
LARGE_INTESTINE	CCNJ →	+0.690	+3.364	.001	.002	3	1
LARGE_INTESTINE	MAPK8 →	+0.806	+3.537	<.001	.001	3	1
LARGE_INTESTINE	BMPR1A →	+0.752	+3.451	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 265 associations by consensus.

SLC39A12 by TBR1 expression — LUNG_SCLC

Explore this box plot interactively →