TBP

Across TCGA patient cohorts, TBP mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBP-associated genes across cancer lineages are STAT3_pY705, A-Raf_pS299, and FASN. Each is linked with TBP in more than 1 cancer types. Because this analysis shows association rather than direction, both TBP-to-partner and partner-to-TBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by TBP-low versus TBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBP→partner) and Y-score (partner→TBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.396	-3.169	<.001	.018	3	2
UCEC	A-Raf_pS299 →	-0.197	-3.584	<.001	.002	3	1
UCEC	FASN →	+0.392	+3.321	.022	.010	3	1
UCEC	Ku80 →	+0.271	+2.820	.008	.001	3	1
UCEC	Notch1 →	+0.169	+3.469	.006	.002	3	1
UCEC	p62 Lck ligand →	+0.376	+3.331	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

STAT3_pY705 by TBP expression — UCEC

Explore this box plot interactively →