TBP

Across TCGA cell cohorts, TBP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,960 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TBP-associated GO terms across cancer lineages are RNA polymerase I preinitiation complex assembly, Negative regulation of ubiquitin protein ligase activity, and Regulation of sister chromatid segregation. Each is linked with TBP in more than 18 cancer types. Because this analysis shows association rather than direction, both TBP-to-partner and partner-to-TBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA polymerase I preinitiation complex assembly grouped by TBP-low versus TBP-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBP→partner) and Y-score (partner→TBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RNA polymerase I preinitiation complex assembly →	+0.127	+0.596	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Negative regulation of ubiquitin protein ligase activity →	+0.220	+1.126	<.001	<.001	3	18
BREAST	Regulation of sister chromatid segregation →	+0.110	+0.815	.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.133	+0.724	<.001	<.001	3	18
LARGE_INTESTINE	Microtubule organizing center organization →	+0.087	+0.955	<.001	<.001	3	17
BONE	Regulation of chromosome organization →	+0.102	+0.572	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,960 associations by consensus.

RNA polymerase I preinitiation complex assembly by TBP expression — SOFT_TISSUE

Explore this box plot interactively →