TBP

Across TCGA cell cohorts, TBP mutation is significantly associated with the mutation status of many other genes, with 2,998 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBP-associated genes across cancer lineages are HNF1B, CSRNP3, and ITCH. Each is linked with TBP in more than 3 cancer types. Because this analysis shows association rather than direction, both TBP-to-partner and partner-to-TBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HNF1B grouped by TBP-low versus TBP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBP→partner) and Y-score (partner→TBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HNF1B →	+4.321	+5.285	.005	.005	1	4
LARGE_INTESTINE	CSRNP3 →	+3.584	+3.007	.008	.008	1	4
LARGE_INTESTINE	ITCH →	+2.678	+2.807	.006	.006	1	3
BLOOD_Leukemia	KLF7 →	+6.321	+6.321	.001	.001	1	3
BLOOD_Leukemia	STX11 →	+4.000	+5.050	.008	.008	1	3
BLOOD_Leukemia	NOSTRIN →	+6.321	+6.321	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,998 associations by consensus.

HNF1B by TBP expression — BLOOD_Leukemia

Explore this box plot interactively →