TBP

Across TCGA cell cohorts, TBP mutation is significantly associated with the drug of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBP-associated genes across cancer lineages are PCI-34051, CI-1033, and 150412. Each is linked with TBP in more than 1 cancer types. Because this analysis shows association rather than direction, both TBP-to-partner and partner-to-TBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCI-34051 grouped by TBP-low versus TBP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBP→partner) and Y-score (partner→TBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PCI-34051 →	+0.410	+2.646	.033	.047	3	1
LARGE_INTESTINE	CI-1033 →	+0.798	+2.652	.007	.045	3	1
LARGE_INTESTINE	150412 →	+0.335	+2.777	.048	.038	2	1
LARGE_INTESTINE	Nutlin-3a (-) →	+0.789	+2.646	.031	.047	1	1
LARGE_INTESTINE	PFI3 →	+0.233	+2.646	.047	.047	1	1
LARGE_INTESTINE	50869 →	+0.442	+2.649	.037	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PCI-34051 by TBP expression — LARGE_INTESTINE

Explore this box plot interactively →