TBL1XR1

Across TCGA patient cohorts, TBL1XR1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBL1XR1-associated genes across cancer lineages are eIF4E, INPP4B, and mTOR_pS2448. Each is linked with TBL1XR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBL1XR1-to-partner and partner-to-TBL1XR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TBL1XR1-low versus TBL1XR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBL1XR1→partner) and Y-score (partner→TBL1XR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.147	+2.070	.016	.001	3	2
UCEC	INPP4B →	-0.224	-1.765	.017	.011	3	2
UCEC	mTOR_pS2448 →	-0.125	-1.912	.003	.004	3	2
UCEC	p27_pT157 →	-0.037	-2.401	.026	.002	3	2
UCEC	ASNS →	+0.338	+1.847	.001	.007	3	2
UCEC	ATM →	-0.545	-2.489	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eIF4E by TBL1XR1 expression — UCEC

Explore this box plot interactively →