TBL1XR1

Across TCGA pan-cancer cohorts, TBL1XR1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated TBL1XR1 data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher TBL1XR1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TBL1XR1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and SKCM show a favorable association.

LIHC, ACC, and KIRP are the cancer types where TBL1XR1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.580	0.773	<.001	74	view →
ACC	DFS	Median	All	0.200	0.670	<.001	69	view →
KIRP	DFS	Tertile	All	0.760	0.924	<.001	39	view →
LUSC	OS	Quartile	II,III,IV	0.744	0.347	.007	30	view →
UCEC	DFS	Quartile	All	0.547	0.860	<.001	30	view →
STAD	DFS	Quartile	IV	0.158	0.715	.006	29	view →
PAAD	OS	Tertile	All	0.281	0.575	.007	29	view →
SKCM	DFS	Quartile	All	0.287	0.126	.001	26	view →
GBM	OS	Tertile	All	0.544	0.251	<.001	25	view →
SARC	OS	Tertile	All	0.384	0.628	.001	18	view →
UCS	DFS	Tertile	IV	0.875	0.364	.024	12	view →
LUAD	DFS	Quartile	III,IV	0.752	0.351	.025	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

TBL1XR1–LIHC (OS)

Open the LIHC breakdown →