TBL1XR1-AS1

Across TCGA pan-cancer cohorts, TBL1XR1-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TBL1XR1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TBL1XR1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TBL1XR1-AS1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where TBL1XR1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBL1XR1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.137	<.001	10	view →
COAD	Male	II,III,IV	+0.193	<.001	9	view →
KIRC	All	All	+0.112	<.001	9	view →
LUSC	Male	II,III,IV	+0.447	<.001	7	view →
BRCA	All	All	+0.301	<.001	4	view →
BLCA	Female	All	+0.288	.031	4	view →
UCEC	All	II,III,IV	+0.238	.012	4	view →
LUAD	Female	II,III,IV	+0.187	<.001	4	view →
STAD	All	All	+0.143	.013	3	view →
PRAD	All	All	+0.181	.048	2	view →
LIHC	Female	II,III,IV	+0.056	.001	2	view →
THCA	Female	II,III,IV	−0.159	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TBL1XR1-AS1–HNSC

Open the HNSC breakdown →