TBL1X

Across TCGA patient cohorts, TBL1X mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBL1X-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and FASN. Each is linked with TBL1X in more than 2 cancer types. Because this analysis shows association rather than direction, both TBL1X-to-partner and partner-to-TBL1X results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TBL1X-low versus TBL1X-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBL1X→partner) and Y-score (partner→TBL1X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.370	+1.534	.032	.008	3	3
UCEC	C-Raf →	+0.163	+1.938	<.001	.001	3	3
UCEC	FASN →	+0.331	+1.514	.003	.014	3	2
UCEC	mTOR_pS2448 →	-0.103	-2.209	.017	.009	3	2
UCEC	Notch1 →	+0.130	+1.295	.001	.010	3	2
UCEC	PCNA →	+0.164	+1.514	.009	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Caspase-7-cleavedD198 by TBL1X expression — UCEC

Explore this box plot interactively →