TBL1X

Across TCGA pan-cancer cohorts, TBL1X RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated TBL1X data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TBL1X RNA is associated with better overall survival. In most high-consensus cancer types, elevated TBL1X expression acts as an unfavorable survival marker, although some lineages such as KIRC and PAAD show a favorable association.

KIRC, PAAD, and HNSC are the cancer types where TBL1X RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.745	0.525	<.001	97	view →
PAAD	OS	Median	All	0.711	0.426	<.001	60	view →
HNSC	DFS	Quartile	IV	0.714	0.466	<.001	51	view →
LIHC	OS	Tertile	All	0.692	0.862	<.001	34	view →
ACC	DFS	Quartile	All	0.261	0.891	.009	24	view →
COAD	DFS	Tertile	All	0.318	0.741	.001	22	view →
MESO	DFS	Quartile	All	0.306	0.760	.026	18	view →
THCA	OS	Median	II,III,IV	0.852	0.979	.012	16	view →
THYM	DFS	Tertile	III,IV	1.000	0.315	.008	16	view →
BRCA	OS	Quartile	All	0.493	0.746	.010	10	view →
TGCT	DFS	Quartile	All	0.925	0.655	.007	10	view →
KICH	DFS	Median	II,III,IV	1.000	0.662	.015	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

TBL1X–KIRC (OS)

Open the KIRC breakdown →