Across TCGA patient cohorts, TBKBP1 mutation is significantly associated with the RNA expression of many other genes, with 1,428 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBKBP1-associated genes across cancer lineages are DEFB130D, MIR520E, and OR4B2P. Each is linked with TBKBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBKBP1-to-partner and partner-to-TBKBP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBKBP1→partner) and Y-score (partner→TBKBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DEFB130D →	+0.078	+2.328	.008	.009	3	3
BLCA	MIR520E →	+0.332	+4.618	<.001	.005	3	2
SKCM	OR4B2P →	+0.035	+4.743	<.001	.005	3	2
STAD	RNU5F-2P →	+0.581	+4.252	<.001	.003	3	2
LUAD	MIR323A →	+0.298	+7.930	<.001	.008	3	2
LUAD	MIR411 →	+1.501	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,428 associations by consensus.

Exploration

TBKBP1 survival (RNA) · tumor vs normal (RNA) · all TBKBP1 data types