TBCD

Across TCGA patient cohorts, TBCD mutation is significantly associated with the RNA expression of many other genes, with 3,147 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBCD-associated genes across cancer lineages are MIR6885, MIR548N, and IGHD4-4. Each is linked with TBCD in more than 3 cancer types. Because this analysis shows association rather than direction, both TBCD-to-partner and partner-to-TBCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6885 grouped by TBCD-low versus TBCD-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBCD→partner) and Y-score (partner→TBCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR6885 →	+0.375	+3.629	<.001	.005	3	4
KIRP	MIR548N →	+0.695	+3.804	.001	.009	3	3
COAD	IGHD4-4 →	+0.769	+3.135	<.001	.008	3	3
SKCM	ATF4P2 →	+0.031	+2.434	<.001	.004	3	3
LUSC	RN7SL483P →	+0.120	+3.857	<.001	.003	3	3
LIHC	RNA5SP527 →	+0.336	+4.049	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,147 associations by consensus.

MIR6885 by TBCD expression — LUAD

Explore this box plot interactively →