TBCC

Across TCGA pan-cancer cohorts, TBCC mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TBCC data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TBCC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBCC expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

COAD, LSCC, and LUAD are the cancer types where TBCC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.869	1.000	.008	84	view →
LSCC	DFS	Quartile	All	0.896	0.486	.003	27	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →
PDAC	DFS	Median	All	0.877	0.720	.035	2	view →
HNSC	OS	Median	All	0.806	0.900	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TBCC–COAD (DFS)

Open the COAD breakdown →