TBC1D8B

Across TCGA pan-cancer cohorts, TBC1D8B Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TBC1D8B data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TBC1D8B Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TBC1D8B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, OV, and COAD are the cancer types where TBC1D8B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.961	0.604	<.001	36	view →
OV	OS	Median	III,IV	0.538	0.837	.005	28	view →
COAD	OS	Median	III,IV	0.157	0.791	.001	12	view →
LGG	DFS	Median	All	0.185	0.826	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TBC1D8B–UCEC (DFS)

Open the UCEC breakdown →