TBC1D8B

Across TCGA patient cohorts, TBC1D8B mutation is significantly associated with the RNA expression of many other genes, with 5,136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D8B-associated genes across cancer lineages are CCNB2, PKN3, and PMPCA. Each is linked with TBC1D8B in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D8B-to-partner and partner-to-TBC1D8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNB2 grouped by TBC1D8B-low versus TBC1D8B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D8B→partner) and Y-score (partner→TBC1D8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCNB2 →	+0.699	+2.169	<.001	<.001	3	3
UCEC	PKN3 →	+0.760	+2.180	<.001	<.001	3	3
UCEC	PMPCA →	+0.417	+2.202	<.001	<.001	3	3
UCEC	ZMYND19 →	+0.452	+1.873	<.001	<.001	3	3
UCEC	PLK1 →	+0.548	+1.691	<.001	<.001	3	3
UCEC	MRM3 →	+0.427	+1.457	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,136 associations by consensus.

CCNB2 by TBC1D8B expression — UCEC

Explore this box plot interactively →