TBC1D8B

Across TCGA patient cohorts, TBC1D8B mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D8B-associated genes across cancer lineages are MSH6, eIF4E, and ASNS. Each is linked with TBC1D8B in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D8B-to-partner and partner-to-TBC1D8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by TBC1D8B-low versus TBC1D8B-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D8B→partner) and Y-score (partner→TBC1D8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MSH6 →	+0.428	+3.204	.025	.009	3	3
UCEC	eIF4E →	+0.206	+1.669	<.001	<.001	3	3
UCEC	ASNS →	+0.336	+1.530	<.001	.003	3	3
UCEC	ATM →	-0.552	-1.502	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.717	+1.669	<.001	<.001	3	3
UCEC	eEF2 →	+0.271	+2.087	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

MSH6 by TBC1D8B expression — BLCA

Explore this box plot interactively →