TBC1D8B

Across TCGA cell cohorts, TBC1D8B mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D8B-associated genes across cancer lineages are PDHA2, OR8B12, and ZNF831. Each is linked with TBC1D8B in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D8B-to-partner and partner-to-TBC1D8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDHA2 grouped by TBC1D8B-low versus TBC1D8B-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D8B→partner) and Y-score (partner→TBC1D8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PDHA2 →	+0.026	+5.029	<.001	.006	3	1
LUNG_SCLC	OR8B12 →	+0.021	+5.029	.001	.006	3	1
LARGE_INTESTINE	ZNF831 →	+0.010	+2.688	<.001	.008	3	1
LARGE_INTESTINE	ECE2 →	+0.205	+2.791	.004	.005	3	1
LARGE_INTESTINE	RGPD3 →	+0.168	+3.169	.003	.009	3	1
LARGE_INTESTINE	FMR1NB →	+0.184	+3.038	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PDHA2 by TBC1D8B expression — LUNG_SCLC

Explore this box plot interactively →