TBC1D8-AS1

Across TCGA pan-cancer cohorts, TBC1D8-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TBC1D8-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TBC1D8-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types TBC1D8-AS1 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and KICH are the cancer types where TBC1D8-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBC1D8-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.675	<.001	11	view →
COAD	Female	II,III,IV	−0.383	<.001	10	view →
KICH	Male	All	−1.510	<.001	8	view →
HNSC	Male	IV	+0.447	<.001	8	view →
LIHC	All	II,III,IV	+0.315	<.001	8	view →
KIRC	Male	II,III,IV	−0.485	<.001	6	view →
LUSC	All	All	+0.498	<.001	5	view →
KIRP	All	All	−0.479	<.001	5	view →
STAD	Male	II,III,IV	+0.427	.013	4	view →
CHOL	All	All	+1.093	<.001	3	view →
BLCA	Female	III,IV	+0.852	.010	2	view →
ESCA	All	II,III,IV	+0.659	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TBC1D8-AS1–THCA

Open the THCA breakdown →