TBC1D7

Across TCGA pan-cancer cohorts, TBC1D7 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TBC1D7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TBC1D7 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TBC1D7 is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and LSCC are the cancer types where TBC1D7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBC1D7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.982	<.001	10	view →
CCRCC	Male	All	−0.157	.013	2	view →
LSCC	Male	All	+0.063	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

TBC1D7–COAD

Open the COAD breakdown →