TBC1D7

Across TCGA pan-cancer cohorts, TBC1D7 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TBC1D7 data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TBC1D7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBC1D7 expression acts as an unfavorable survival marker, although some lineages such as OV and READ show a favorable association.

UVM, BRCA, and ACC are the cancer types where TBC1D7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.434	0.869	<.001	86	view →
BRCA	DFS	Median	III,IV	0.707	0.885	<.001	85	view →
ACC	DFS	Median	All	0.254	0.641	<.001	80	view →
MESO	OS	Tertile	All	0.243	0.578	<.001	79	view →
LIHC	OS	Median	All	0.704	0.845	<.001	54	view →
KIRC	DFS	Quartile	All	0.736	0.871	.001	51	view →
OV	OS	Median	III,IV	0.382	0.261	<.001	42	view →
KICH	OS	Quartile	II,III,IV	0.488	1.000	.003	30	view →
SKCM	OS	Quartile	All	0.724	0.870	.001	22	view →
SARC	DFS	Tertile	All	0.548	0.726	.003	22	view →
READ	DFS	Tertile	III,IV	0.682	0.326	.013	21	view →
ESCA	OS	Tertile	III,IV	0.301	0.611	.013	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TBC1D7–UVM (DFS)

Open the UVM breakdown →