TBC1D7

Across TCGA patient cohorts, TBC1D7 mutation is significantly associated with the RNA expression of many other genes, with 3,207 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D7-associated genes across cancer lineages are RN7SKP221, LSP1P1, and SDC4P. Each is linked with TBC1D7 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D7-to-partner and partner-to-TBC1D7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP221 grouped by TBC1D7-low versus TBC1D7-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D7→partner) and Y-score (partner→TBC1D7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	2
UCEC	LSP1P1 →	+0.222	+1.943	.001	.001	3	2
COAD	SDC4P →	+0.144	+5.283	.001	.006	3	2
READ	OR6J1 →	+0.063	+4.925	<.001	.004	3	2
READ	MIR4774 →	+0.627	+5.257	<.001	.002	3	2
UCEC	RNU6-249P →	+0.236	+1.940	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,207 associations by consensus.

RN7SKP221 by TBC1D7 expression — BRCA

Explore this box plot interactively →