TBC1D7

Across TCGA cell cohorts, TBC1D7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,030 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TBC1D7-associated GO terms across cancer lineages are Chromosomal 5-methylcytosine DNA demethylation pathway, Negative regulation of RNA export from nucleus, and Positive regulation of developmental pigmentation. Each is linked with TBC1D7 in more than 8 cancer types. Because this analysis shows association rather than direction, both TBC1D7-to-partner and partner-to-TBC1D7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chromosomal 5-methylcytosine DNA demethylation pathway grouped by TBC1D7-low versus TBC1D7-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D7→partner) and Y-score (partner→TBC1D7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.154	+0.619	<.001	.004	3	9
OESOPHAGUS	Negative regulation of RNA export from nucleus →	+0.113	+0.791	.009	<.001	3	9
LUNG_NSCLC_LUAD	Positive regulation of developmental pigmentation →	+0.132	+0.845	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Anterograde synaptic vesicle transport →	+0.079	+0.952	<.001	<.001	3	8
LUNG_NSCLC_LUAD	Regulation of pigment cell differentiation →	+0.155	+0.938	<.001	<.001	3	8
LUNG_NSCLC_LUAD	Positive regulation of pigment cell differentiation →	+0.155	+0.938	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,030 associations by consensus.

Chromosomal 5-methylcytosine DNA demethylation pathway by TBC1D7 expression — LUNG_SCLC

Explore this box plot interactively →