TBC1D3I

Across TCGA pan-cancer cohorts, TBC1D3I RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated TBC1D3I data layer compared with 1 for mutation status.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher TBC1D3I RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TBC1D3I expression acts as an unfavorable survival marker, although some lineages such as KIRP and SARC show a favorable association.

DLBC, KICH, and UCEC are the cancer types where TBC1D3I RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	II,III,IV	0.214	0.899	<.001	54	view →
KICH	OS	Tertile	All	0.191	0.875	.001	36	view →
UCEC	DFS	Tertile	IV	0.459	0.728	.003	36	view →
LIHC	DFS	Tertile	All	0.172	0.468	<.001	27	view →
THCA	OS	Tertile	IV	0.790	1.000	.016	21	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	18	view →
GBM	OS	Quartile	All	0.317	0.433	.039	3	view →
KIRP	DFS	Tertile	All	0.980	0.896	.043	3	view →
HNSC	DFS	Tertile	II,III,IV	0.507	0.686	.047	3	view →
SARC	DFS	Tertile	All	0.862	0.599	.033	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

TBC1D3I–DLBC (OS)

Open the DLBC breakdown →