Across TCGA pan-cancer cohorts, TBC1D3G RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of TBC1D3G’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where TBC1D3G RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TBC1D3G is over-expressed in tumor.
BLCA and LUSC are the cancer types where TBC1D3G tumor–normal differential expression is most reproducible.