TBC1D3C

Across TCGA patient cohorts, TBC1D3C RNA expression is significantly associated with the go_rna of many other GO terms, with 3,680 significant associations in total. THYM shows the largest number of these associations.

The most reproducible TBC1D3C-associated GO terms across cancer lineages are Telomere tethering at nuclear periphery, Regulation of cytochrome-c oxidase activity, and Positive regulation of translation in response to stress. Each is linked with TBC1D3C in more than 7 cancer types. Because this analysis shows association rather than direction, both TBC1D3C-to-partner and partner-to-TBC1D3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomere tethering at nuclear periphery grouped by TBC1D3C-low versus TBC1D3C-high in THYM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D3C→partner) and Y-score (partner→TBC1D3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	Telomere tethering at nuclear periphery →	-0.078	-0.015	<.001	.001	3	7
PAAD	Regulation of cytochrome-c oxidase activity →	+0.039	+0.008	<.001	<.001	3	6
THYM	Positive regulation of translation in response to stress →	-0.072	-0.021	<.001	.001	3	6
THYM	rRNA base methylation →	+0.031	+0.016	<.001	.002	3	6
STAD	COPII-coated vesicle cargo loading →	-0.068	-0.003	<.001	.003	2	7
UCEC	Multi-pass transmembrane protein insertion into ER membrane →	+0.038	+0.003	<.001	.005	1	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,680 associations by consensus.

Telomere tethering at nuclear periphery by TBC1D3C expression — THYM

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