TBC1D3C

Across TCGA pan-cancer cohorts, TBC1D3C RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TBC1D3C data layer.

The strongest signal is observed in testicular germ cell tumors (TGCT), where higher TBC1D3C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBC1D3C expression acts as an unfavorable survival marker, although some lineages such as OV and SCLC show a favorable association.

TGCT, UCS, and KICH are the cancer types where TBC1D3C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
TGCT	DFS	Tertile	III,IV	0.010	1.000	<.001	102	view →
UCS	DFS	Tertile	IV	0.290	0.752	.028	72	view →
KICH	DFS	Tertile	II,III,IV	0.035	0.860	<.001	54	view →
ACC	OS	Tertile	All	0.127	0.639	<.001	45	view →
OV	DFS	Tertile	III,IV	0.684	0.518	.007	42	view →
CESC	OS	Tertile	IV	0.164	0.612	.013	36	view →
UCEC	OS	Tertile	IV	0.066	0.755	<.001	36	view →
THCA	DFS	Tertile	All	0.444	0.823	.006	30	view →
DLBC	OS	Tertile	II,III,IV	0.115	0.839	<.001	27	view →
UVM	DFS	Tertile	III,IV	0.032	0.727	<.001	18	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	18	view →
ESCA	OS	Tertile	II,III,IV	0.105	0.867	.016	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TBC1D3C–TGCT (DFS)

Open the TGCT breakdown →