TBC1D3B

Across TCGA patient cohorts, TBC1D3B mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D3B-associated genes across cancer lineages are eIF4G, Shc_pY317, and Cyclin-B1. Each is linked with TBC1D3B in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D3B-to-partner and partner-to-TBC1D3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by TBC1D3B-low versus TBC1D3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D3B→partner) and Y-score (partner→TBC1D3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.396	+2.999	.014	.035	3	1
UCEC	Shc_pY317 →	-0.201	-3.000	.011	.036	3	1
UCEC	Cyclin-B1 →	+0.659	+3.000	.025	.036	3	1
UCEC	MEK1 →	+0.576	+3.321	.002	.010	2	1
UCEC	N-Cadherin →	+0.335	+3.321	.002	.010	2	1
UCEC	4E-BP1 →	+0.418	+2.837	.003	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

eIF4G by TBC1D3B expression — UCEC

Explore this box plot interactively →