TBC1D3B

Across TCGA pan-cancer cohorts, TBC1D3B RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TBC1D3B data layer compared with 2 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher TBC1D3B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBC1D3B expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

MESO, SKCM, and KIRC are the cancer types where TBC1D3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	III,IV	0.239	0.488	<.001	56	view →
SKCM	DFS	Quartile	III,IV	0.639	0.317	.001	55	view →
KIRC	OS	Tertile	All	0.541	0.769	<.001	42	view →
ACC	DFS	Quartile	II,III,IV	0.260	0.777	.002	31	view →
THCA	DFS	Tertile	II,III,IV	0.549	0.901	<.001	30	view →
DLBC	DFS	Median	All	0.586	0.960	.001	25	view →
LUSC	DFS	Quartile	III,IV	0.309	0.993	.009	25	view →
LGG	DFS	Tertile	All	0.761	0.872	<.001	23	view →
LIHC	DFS	Tertile	II,III,IV	0.244	0.374	.024	17	view →
KIRP	OS	Quartile	III,IV	0.240	0.879	.008	16	view →
LUAD	DFS	Tertile	IV	0.418	0.921	.005	14	view →
READ	DFS	Quartile	III,IV	0.561	0.870	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TBC1D3B–MESO (DFS)

Open the MESO breakdown →