TBC1D31

Across TCGA patient cohorts, TBC1D31 mutation is significantly associated with the RNA expression of many other genes, with 4,175 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D31-associated genes across cancer lineages are RNU7-54P, DRD2, and SLC7A11. Each is linked with TBC1D31 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D31-to-partner and partner-to-TBC1D31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-54P grouped by TBC1D31-low versus TBC1D31-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D31→partner) and Y-score (partner→TBC1D31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU7-54P →	+0.298	+4.393	.001	.008	3	3
UCEC	DRD2 →	-0.379	-1.701	.001	<.001	3	2
UCEC	SLC7A11 →	+0.699	+2.595	<.001	<.001	3	2
UCEC	NOCT →	+0.613	+1.733	<.001	<.001	3	2
UCEC	THRB →	-0.480	-1.519	.006	.001	3	2
UCEC	OXSM →	+0.229	+1.217	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,175 associations by consensus.

RNU7-54P by TBC1D31 expression — LUSC

Explore this box plot interactively →