TBC1D31

Across TCGA pan-cancer cohorts, TBC1D31 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of TBC1D31’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TBC1D31 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TBC1D31 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BLCA, and STAD are the cancer types where TBC1D31 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBC1D31 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+1.019	<.001	12	view →
BLCA	Male	III,IV	+1.297	<.001	11	view →
STAD	Female	All	+1.375	<.001	10	view →
LUAD	Male	III,IV	+1.261	<.001	10	view →
COAD	All	III,IV	+0.806	<.001	10	view →
LIHC	Male	All	+1.028	<.001	9	view →
LUSC	Female	II,III,IV	+1.214	<.001	8	view →
UCEC	All	II,III,IV	+1.020	<.001	8	view →
KIRC	Male	All	+0.256	<.001	8	view →
KIRP	All	II,III,IV	+0.500	.003	7	view →
BRCA	All	II,III,IV	+0.914	<.001	6	view →
READ	All	All	+0.828	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

TBC1D31–HNSC

Open the HNSC breakdown →