TBC1D31

Across TCGA patient cohorts, TBC1D31 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D31-associated genes across cancer lineages are 14-3-3_beta, FoxM1, and Ku80. Each is linked with TBC1D31 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D31-to-partner and partner-to-TBC1D31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TBC1D31-low versus TBC1D31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D31→partner) and Y-score (partner→TBC1D31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.068	-1.388	.020	.041	3	2
UCEC	FoxM1 →	+0.158	+1.485	.036	.003	3	2
UCEC	Ku80 →	+0.224	+1.920	.001	<.001	3	2
UCEC	MAPK_pT202_Y204 →	-0.277	-1.321	.043	.027	3	2
UCEC	PDCD4 →	-0.612	-2.321	<.001	<.001	3	2
UCEC	Rab25 →	-0.344	-2.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

14-3-3_beta by TBC1D31 expression — UCEC

Explore this box plot interactively →