TBC1D31

Across TCGA cell cohorts, TBC1D31 mutation is significantly associated with the RNA expression of many other genes, with 373 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D31-associated genes across cancer lineages are IQCF5, OR56A1, and OR52N1. Each is linked with TBC1D31 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D31-to-partner and partner-to-TBC1D31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by TBC1D31-low versus TBC1D31-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D31→partner) and Y-score (partner→TBC1D31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	2
LUNG_NSCLC_LUAD	OR56A1 →	+0.401	+5.189	<.001	<.001	3	2
LUNG_NSCLC_LUAD	OR52N1 →	+0.040	+4.544	.008	.003	3	2
UPPER_AERODIGESTIVE_TRACT	GPR101 →	+0.106	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	PABPC1L2B →	+0.203	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.027	+4.736	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 373 associations by consensus.

IQCF5 by TBC1D31 expression — BLOOD_Leukemia

Explore this box plot interactively →